Must look at current research in PubMed. MTHFR just identified around 1998, variants in 2001 and 2003. 35-50% of Americans affected with this gene polymorphism. Mandatory folic acid fortification in our foods since January 1, 1998.
http://www.ncbi.nlm.nih.gov/pubmed/19455642
http://www.ncbi.nlm.nih.gov/pubmed/21069446
http://www.ncbi.nlm.nih.gov/pubmed/19440165
http://www.ncbi.nlm.nih.gov/pubmed/19267885

Mark Hyman, MD (has MTHFR, iirc) has been making connections.
http://medicineworks.com/folic-acid-killer-or-cure-all-mark-hyman-md

And Stephen Smith, MD:
http://www.mindmeister.com/12721370/mthfr-treatment
http://www.mindmeister.com/12694596/mthfr-related-health-problems

And Neil Rawlins. MD (has MTHFR, iirc):
http://www.renewashoe.com/medical/
http://www.nwhealthcare.net/index.php?id=40
http://www.rawlins.org/mthfr/mthfr.html

And Joel Fuhrman, MD:
http://www.drfuhrman.com/library/folic_acid_dangers_and_prenatal_vi...

"We" mandate folic acid in prenatal vitamins and this is not metabolized properly by the 40% of the population with MTHFR and thus food folate is less able to be utilized. Concurrently, we are having increased rates of impaired detoxification (with MTHFR and impaired methylation due to folic acid fortification) and increased ASD (which has some genetic connection).

Here is more again: http://www.mothering.com/community/forum/thread/1184692/real-folate...

 

Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review.
http://www.ncbi.nlm.nih.gov/pubmed/17074966
http://aje.oxfordjournals.org/content/165/1/1.full

 

MTHFR genetic polymorphism and autism spectum disorders.
http://heal-thyself.ning.com/profiles/blogs/mthfr-1
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2610366/
http://74.125.155.132/scholar?q=cache:cmtcxvbrAD0J:scholar.google.c...

 

Folate pathway genetic polymorphisms are related to attention disorders.
http://www.ncbi.nlm.nih.gov/pubmed/18154909
http://www.ncbi.nlm.nih.gov/pubmed/20870238

 

Meta-analysis of genetic studies on major depressive disorder.
http://www.ncbi.nlm.nih.gov/pubmed/17938638

 

More from Kenneth Bock, MD:

http://www.autismone.org/content/healing-new-childhood-epidemics-th...

 

Here is more about the Nutrigenomics related to the MTHFR gene.

 



general info here: http://heal-thyself.ning.c om/forum/topics/mthfr-c677 t-folate

more extensive lay explanation: http://heal-thyself.ning.c om/profiles/blogs/folate-v s-folic-acid

great tutorial (video) about homocysteine: http://heal-thyself.ning.c om/video/homocysteine-1

The Basics: http://www.detoxpuzzle.com /mthfr.php

chart of folate pathways: http://heal-thyself.ning.c om/group/nutritionbiochemi stry/forum/topics/folic-ac id-cycle

food sources: http://heal-thyself.ning.c om/forum/topics/folate-1

 

 

 

For more information about healing naturally, keep updated on Facebook  Heal Thyself! 
Overwhelmed? Where to start?     ~Become your own Gut Guru!

 

Welcome, we hope you will join us!

 

Pat RobinsonWellness Educator

 

 

P.S. Favorite Posts:

     •  14 Steps For Healthy Guts

     •  The Beet Test (stomach acid?) 

     •  Candida 101 

     •  Green Smoothie Challenge

     •  Healthy Poop 101

     •  Master Tonic 101 

     •  Nettle Leaf herbal infusions 101.

     •  Overwhelmed? Where to Start?!

     •  Probiotic Selection

P.P.S.  •  Favorite Topics        •  Extensive Video Library     •  Join in the discussions! 

 

 

Views: 13345

Comment by Pat Robinson on October 12, 2011 at 10:35am
Start here: http://mthfr.net/

Detox Puzzle: http://www.detoxpuzzle.com/
Eating Cultures: http://www.eatingcultures.com/tikiwiki-2.2/tiki-index.php

(those two are helpful for identifying blocked detox pathways)

More about detox pathways: http://heal-thyself.ning.com/forum/topics/detox-obstacle-course

the long version: http://www.tuberose.com/Liver_Detoxification.html

Basically, 40% of the American population has the MTHFR gene polymorphism. The concern is not being able to utilize synthetic folic acid for effective detoxification. So, we end up with toxin overload issues, especially heavy metals. Food folate, B6 and B12 and magnesium help to detox properly. They are available in food. Dr. Lynch has supplements available for the MTHFR population. We disagree (a bit) about food as the primary source of nutrients. :-)

Tongue-tie is one of about 50 disorders associated with the MTHFR gene. http://mthfr.net/mthfr-mutations-and-the-conditions-they-cause/2011...
Comment by Pat Robinson on October 12, 2011 at 10:36am
Comment by Aischa Ibnouzahir on August 1, 2012 at 6:10pm

Holy Moly, this is one lab I regret googling! All of a sudden I feel like I am at the bottom of a cliff, wondering how to get up it.

On the positive side, knowledge beats repeatedly seeking help from the regular Doctor's office (as opposed to the Functional Medicine Doctor) and keep getting brushed aside with band-aid prescriptions and no answers, or things to try.

I'll have to start reading, even though it looks like it is enough material to last a whole semester.

Thanks!

Comment by Pat Robinson on August 1, 2012 at 7:31pm

Welcome, glad/sorry you found us, iykwim. {{{hugs}}}

Consider starting an "About Me" thread in the Wellness Forum with your history, health issues, alternatives you tried... we'll chime in to help trouble-shoot.


Pat

Comment by Pat Robinson on September 7, 2012 at 8:24am

This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.

http://www.ncbi.nlm.nih.gov/pubmed/17074966
http://www.ncbi.nlm.nih.gov/pubmed/22370993
http://www.ncbi.nlm.nih.gov/pubmed/21955385

"High tHcy but low folate and vitamin B12 levels may be a risk factor for development of bipolar disorder."
http://www.ncbi.nlm.nih.gov/pubmed/18513846

Many antipsychotic pharmaceuticals are detoxified by the CYP450 gene/enzyme which is commonly an issue with bipolar, also.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1390790/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC161731/
http://www.ncbi.nlm.nih.gov/pubmed/18537577

Additionally, antipsychotics often impair folate absorption.

Bipolar aggression can be related to folate deficiency. NOT "folic acid", the synthetic vitamin. Folate as 5-MTHF or food folate: beans, greens, liver and legumes.

You might contact Dr Ben Lynch at MTHFR.net: http://mthfr.net/methylfolate-taking-too-much-a-problem/2012/01/08/


MTHFR and Psyciatric Disorders: http://aje.oxfordjournals.org/content/165/1/1.long

pdf version: http://aje.oxfordjournals.org/content/early/2006/10/30/aje.kwj347.full.pdf

Nutritional doses of Lithium Orotate may also be helpful for aggression.
http://www.jacn.org/content/21/1/14.full
http://www.ncbi.nlm.nih.gov/pubmed/1699579
http://www.ncbi.nlm.nih.gov/pubmed/7662499


There is strong evidence that omega-3 fatty acids have a beneficial effect in bipolar disorder.
http://www.greenmedinfo.com/disease/bipolar-disorder

Magnesium deficiency is common, and associated with aggression. http://www.ncbi.nlm.nih.gov/pubmed/3365326

Pat

Comment by Pat Robinson on November 18, 2012 at 9:07am

MTHFR.net and MTHFR-MD are additional resources.


Pat

Comment by Gilla Weiss on February 27, 2013 at 3:46pm

I finally got tested and I have 2 copies of the  A1298C.  Iam having a little "aha" moment here :) where I feel like I have found the missing piece to the puzzle of my personal, unique health.

I have been supplementing with L-5 mthf for a while now, since I did suspect this  and also giving  my kids,  Now that I am positive, I can get my kids tested.  Yay! there is power in knowledge!!   There is so much info here that I need to go back and read, thanks Pat for putting all this info here.

Comment

You need to be a member of Heal Thyself! to add comments!

Join Heal Thyself!

Newsletter

Adrenal Fatigue?

New eCourse: You can feel better. You will feel better!

 

 

Start Here...

                Master Tonic 101

          14 Steps for Healthy Guts

   The Beet Test (stomach acid)

                Healthy Poop 101

Overwhelmed? Where To Start?

                      Candida 101

Signs and Symptoms of Magnesium Deficiency


        Nettle Leaf Infusion 101

            10pm Bedtime Club 14-Day Green Smoothie Challenge

        Sharing Starter Cultures

               Probiotic Selection

       Water Kefir vs. Kombucha         Natural Remedies for Flu

Latest Activity

Christian Bell updated their profile
Dec 3
Kristalina Georgieva updated their profile
Jan 17
Profile IconHollie Ilene Smith, Aisha Al Mazrouei, Stella Abud and 5 more joined Heal Thyself!
Nov 25, 2021
Shelly Robison updated their profile
Jul 9, 2021
Rev W-W updated their profile
Feb 3, 2021
Profile IconMara Stova, Trickels and Lisa Lane joined Heal Thyself!
Dec 11, 2020
Theresa B. Kinscherf updated their profile
Nov 5, 2020
Profile IconChantelle Trudeau, lesley kramer, Stella Abu and 5 more joined Heal Thyself!
Oct 31, 2020
Kelly B updated their profile
Oct 18, 2020
Rhonda is now a member of Heal Thyself!
Sep 25, 2020
Valerie A. Handleton is now a member of Heal Thyself!
Sep 18, 2020
Pat Robinson updated their profile
Feb 15, 2020
Profile IconKailani Fox and ELLEN M. CORNIA joined Heal Thyself!
Feb 1, 2019
Tiffany Compton updated their profile
Jan 17, 2019
Marlis Ahmed updated their profile
Jan 8, 2019
Profile Iconmark mlinaric, Pamela Roberts, JoAnne Wajer and 17 more joined Heal Thyself!
Jan 4, 2019
Profile IconEileen Ortiz, Claudette Russell, Pam Bulluck and 12 more joined Heal Thyself!
Oct 5, 2017
Profile IconDesiree Turner, Elena Reed, Debra Montenegro and 30 more joined Heal Thyself!
Jul 25, 2017
Alisha Kapoor posted a blog post
Jul 25, 2017
Edward Kendal joined Shannon's group
May 24, 2017

Videos

  • Add Videos
  • View All

Disclaimer

Wellness is an active process of personal accountability.

This list shares personal experience and information only and should not be taken as medical advice. All opinions and information shared are the views of the individual member.

Everyone must use her own discretion and judgment to determine whether you are comfortable or need to seek professional assistance. We are not your doctor.

The information contained in these pages is not intended to take the place of your health professional's advice. It is derived from our personal experience and research, and may shed light on your health complaints. In case of serious ailments which may not respond favorably, please seek the counsel of a qualified health professional.


"What do you expect the doctor to do? He can only prescribe something that will mask the symptoms until you heal yourself. He can not heal you."~ Gitti

Heal Thyself!

“Let thy food be thy medicine and thy medicine be thy food.” --Hippocrates (460-377 B.C.)

Blog Posts

Homemade Beauty Tips to Enhance Beauty Naturally

Posted by Alisha Kapoor on August 12, 2016 at 1:19pm

Cancer Vaccines Are Profitable Business

Posted by Pat Robinson on May 5, 2015 at 5:00pm — 1 Comment

Vaccine Safety and the CDC

Posted by Pat Robinson on March 29, 2015 at 7:30pm

I certainly don't fear the measles.

Posted by Pat Robinson on January 23, 2015 at 10:59am — 3 Comments

Gluten-Free Snacks

Posted by Pat Robinson on May 26, 2014 at 8:30pm

Cholesterol 101

Posted by Pat Robinson on May 20, 2014 at 8:00pm

Safe Detox Protocol

Posted by Pat Robinson on May 4, 2014 at 9:00pm

Ella’s Story

Posted by Pat Robinson on April 19, 2014 at 12:00pm

Naturally Sweetened Treats

Posted by Pat Robinson on February 25, 2014 at 7:30pm

© 2024   Created by Pat Robinson.   Powered by

Badges  |  Report an Issue  |  Terms of Service