AA conjugation -

Acetylation -

Glucuronidation -

Methylation - do raw tomatoes turn your skin red?

Sulfation -

Glutathione - how sensitive are you to caffeine?

Views: 228

Reply to This

Replies to This Discussion

sulfation - in/tolerance to sulfa drugs?
Glucuronidation - does kombucha give you a head-rush?
Yes, I usually feel a little drunk after having some - the head rush kind of drunk.
Me too.

If the answers are yes to these questions, (i.e. red skin from tomatoes; sensitive to caffeine; intolerant to sulfa drugs; kombucha gives you a head-rush) that indicates a deficiency in those pathways, correct?

if so, i'm boned, because all of those things are true for me.
This link has some description of testing for fast or slow Phase I and Phase II. http://books.google.com/books?id=ZG9glNfif5YC&pg=PA111&lpg=...

re: above the caffeine and glutathione, I think caffeine is more of an indicator of fast or slow phase 1, separate from whether you have enough glutathione to deal with the free radicals that are produced as a byproduct of phase 1 detoxification. So my husband and both his parents can drink coffee right before bed without it causing sleep problems, so it looks like their phase 1 if fast. But I am rather caffeine sensitive and have had jitters/shakes from relatively small amounts (I've never been a coffee drinker), and I think my phase 1 is slow.

re: sulfa drugs, tuberose says it's acetylation, not sulfation, strangely enough, and it's highly variable from person-to-person.

eta: vitamin C can help deal with those free radicals from phase 1, so it _seems_ like it would have a glutathione-sparing effect, and tuberose does say that ingesting vitC in relatively modest doses increases circulating glutathione. I take it to bowel tolerance, but even a smaller amount seems helpful.
I want to talk a bit more about phase 1 and phase 2, because it's the interaction between these two that has caused me problems, and yet could've been much more complicated and intense to fix it the fit between the two had been worse.

Our livers have a lot of different chemicals to deal with (both chemicals our bodies make, like estrogen, and various things from outside our bodies). Some of these, like caffeine, are dealt with in one step. That is phase 1 detoxification, and caffeine is ready to leave the body after phase 1 deals with it. But some chemicals are perhaps more complex (not sure why they need 2 steps) and so phase 1 starts the processing on those chemicals, but instead of being ready to exit, the are turned into more reactive chemicals so that phase 2 can finish them off. And phase 2 has the 6 pathways that we've been discussing.

A couple problems can occur with mis-matches between phase 1 and phase 2. I tend to have slow phase 1 (as evidenced by caffeine giving me jitters) and slow phase 2. I may have some phase 2 pathways that work fine, but one thing I've noticed is that heavy duty pain relievers (like after a tooth removal) or cold/allergy drugs seem to make me loopier than most folks, or they just knock me out. I think I'm slow detoxifying them, so they circulate in higher levels than in most people.

An ugly, really problematic thing can happen if phase 1 is fast and phase 2 is slow, because phase 1 will create all these highly-reactive chemicals that will then float around the body and cause havoc. I read about this from Andy Cutler (he wrote Amalgam Illness and one or two other books) and people with fast phase 1 and slow phase 2 who have amalgam fillings tend to end up with complicated, really life-altering illnesses like fibromyalgia and multiple chemical sensitivity and stuff like that.
Glutathione can be used to deal with the free radicals that are a by-product of phase 1 detoxification, but glutathione is also used during phase 2 to deal with things like heavy metals.

People who are hypothyroid are almost always low in things like zinc and selenium, which are needed for glutathione production. Almost everyone on the mercury chelation yahoo groups has thyroid and/or adrenal problems, usually both (not saying everyone with adrenal or thyroid problems has mercury issues, but it helped form a pattern for me).
This helped me to have more clarity about the two phases. I get jittery with small amounts of caffeine.

Thanks, Pat
I have the same thing, that I used to metabolize meds very slowly, because a dose would have a much more profound effect on me. I haven't taken any pharmaceutical meds in over 10 years, but when I did, a small dose ofpain reliever would knock me out. They need to be testing this stuff to determine an individual's dose for a certain med. That may be why my kids had such damage form one round of abx, while most people say, one round of abx won't mess things up that bad. Well, it can if it's hanging around in your system a lot longer than in other folks. It's the same for vaccines.
do you know how you respond to sulfa drugs?

Reply to Discussion



Adrenal Fatigue?

New eCourse: You can feel better. You will feel better!



Start Here...

                Master Tonic 101

          14 Steps for Healthy Guts

   The Beet Test (stomach acid)

                Healthy Poop 101

Overwhelmed? Where To Start?

                      Candida 101

Signs and Symptoms of Magnesium Deficiency

        Nettle Leaf Infusion 101

            10pm Bedtime Club 14-Day Green Smoothie Challenge

        Sharing Starter Cultures

               Probiotic Selection

       Water Kefir vs. Kombucha         Natural Remedies for Flu

Latest Activity

Pat Robinson updated their profile
Feb 15
Kelly B updated their profile
Oct 30, 2019
Profile IconKailani Fox and ELLEN M. CORNIA joined Heal Thyself!
Feb 1, 2019
Tiffany Compton updated their profile
Jan 17, 2019
Marlis Ahmed updated their profile
Jan 8, 2019
Profile Iconmark mlinaric, Pamela Roberts, JoAnne Wajer and 17 more joined Heal Thyself!
Jan 4, 2019
Ronald updated their profile
Oct 9, 2017
Profile IconEileen Ortiz, Claudette Russell, Pam Bulluck and 12 more joined Heal Thyself!
Oct 5, 2017
Profile IconDesiree Turner, Elena Reed, Debra Montenegro and 30 more joined Heal Thyself!
Jul 25, 2017
Alisha Kapoor posted a blog post
Jul 25, 2017
Edward Kendal joined Shannon's group
May 24, 2017
Meg Bennett shared a profile on Facebook
Feb 28, 2017
Meg Bennett is now a member of Heal Thyself!
Feb 28, 2017
Profile IconJudith Anderson, Jo West, Steve Mayer and 7 more joined Heal Thyself!
Nov 24, 2016
Kimberly Daronco shared Pat Robinson's blog post on Facebook
Sep 2, 2016
Kimberly Daronco shared Pat Robinson's blog post on Google +1
Sep 2, 2016
sally willod commented on Pat Robinson's blog post Duration of Long-term Immunity After Hepatitis B Virus Immunization?
Aug 29, 2016
Pat Robinson replied to isis's discussion PLEASE HELP - Molloscum Contagiousum
Aug 16, 2016
isis posted a discussion
Aug 15, 2016
HILARY updated their profile
Aug 4, 2016


  • Add Videos
  • View All


Wellness is an active process of personal accountability.

This list shares personal experience and information only and should not be taken as medical advice. All opinions and information shared are the views of the individual member.

Everyone must use her own discretion and judgment to determine whether you are comfortable or need to seek professional assistance. We are not your doctor.

The information contained in these pages is not intended to take the place of your health professional's advice. It is derived from our personal experience and research, and may shed light on your health complaints. In case of serious ailments which may not respond favorably, please seek the counsel of a qualified health professional.

"What do you expect the doctor to do? He can only prescribe something that will mask the symptoms until you heal yourself. He can not heal you."~ Gitti

Heal Thyself!

“Let thy food be thy medicine and thy medicine be thy food.” --Hippocrates (460-377 B.C.)

Blog Posts

Homemade Beauty Tips to Enhance Beauty Naturally

Posted by Alisha Kapoor on August 12, 2016 at 1:19pm

Cancer Vaccines Are Profitable Business

Posted by Pat Robinson on May 5, 2015 at 5:00pm — 1 Comment

Vaccine Safety and the CDC

Posted by Pat Robinson on March 29, 2015 at 7:30pm

I certainly don't fear the measles.

Posted by Pat Robinson on January 23, 2015 at 10:59am — 3 Comments

Gluten-Free Snacks

Posted by Pat Robinson on May 26, 2014 at 8:30pm

Cholesterol 101

Posted by Pat Robinson on May 20, 2014 at 8:00pm

Safe Detox Protocol

Posted by Pat Robinson on May 4, 2014 at 9:00pm

Ella’s Story

Posted by Pat Robinson on April 19, 2014 at 12:00pm

Naturally Sweetened Treats

Posted by Pat Robinson on February 25, 2014 at 7:30pm

© 2020   Created by Pat Robinson.   Powered by

Badges  |  Report an Issue  |  Terms of Service