~ Food Has Power ~
Let's say that an automobile manufacturer produces a car which randomly accelerates in traffic, or suddenly slows down on the highway --- if you drank grapefruit juice yesterday.
Who would be responsible for the severe traffic accidents ('adverse car reactions') and deaths if the manufacturer did not inform you about the dangers of driving their car when drinking grapefruit juice, lemonade, broccoli, cruciferous vegetables, green/black tea, milk, spinach, carrots, parsley, celery, fennel, etc? What if smoking tobacco might cause the car to react abnormally?
When the MD prescribes buying a certain vehicle, would he be accountable to inform you about the foods which might make that specific car have severe "adverse car reactions" and potentially fatal accidents, before you drive the car?
Would the manufacturer be criminal to clinically test the car for "safety" and "efficacy" with robot drivers who don't eat those foods, but then sell the car to the public without informing them about the dangers of the car when eating and drinking normally?
That is what happens when the pharmaceutical manufacturer produces a drug which becomes toxic in the body, if you drank grapefruit juice yesterday.
When we swallow pharmaceutical chemicals those chemicals must be detoxified by the body. Eating normal foods improves or slows down the way that the liver (primarily) detoxifies chemicals.
Per FDA recommendations, drug manufacturers don't include people in the clinical trials who they know might be harmed by their drugs becoming toxic due to their impaired CY P450 enzyme. But the FDA approves the drug to be sold to the public without informing them about the dangers of the drug for people with the CY P450 enzyme. The MDs prescribe the drug for drug for people without testing for the CY P450 enzyme.
Have you ever experienced an adverse drug reaction? Did your MD report it to the "Adverse Events Reporting System"?
Let's look at specific drugs such as cholesterol-lowering drugs (statins), antidepressants (SSRIs), reflux medications (PPI), many cardiac drugs, antibiotics, pain medications, antihistamines, NSAIDs, anticonvulsants, Coumadin, theophylline, birth control pills, Tylenol --- all can have "adverse drug reactions" due to the CY P450 enzyme.
But, the drug manufacturer, the FDA, the CDC, and the AMA all know that about 20% of Americans have an impairment in the CY P450 enzyme.
In clinical trials they test for the CY P450 enzyme.
And the drug manufacturer, the FDA, the CDC, and the AMA all know that many normal foods impact the chemical toxicity or availability. But, were you told which drugs cause these toxicity effects when eating normal foods?
What if taking a specific medication while driving caused you to drive the car off the highway or into oncoming traffic killing yourself and causing violence to others? Many drugs have a similar effect causing suicide thoughts, self-harm, suicide, violence and aggression toward others.
According to the CDC:
Let's talk about drug-drug interactions when you take two or MORE drugs which must be detoxified by the CY P450 enzyme. Toxicity develops faster as the drug dumps chemicals in an accelerated rate. Or intended drug effects do not occur, if normal foods slow down the chemicals going into the bloodstream.
What about taking FIVE or more prescription drugs at one time?
In the US, the average, 2011:
Total pharmaceutical sales in United States, 2011:
That is $227 BILLION dollars.
But, what if about 20% of the people taking those drugs might become toxic when taking the drugs? What if many people could have "adverse drug reactions" when taking drugs and eating normal foods? How many people have "adverse drug reactions" because they are taking too many drugs for the body to detoxify safely?
What are some of the most severe drug reactions when drinking grapefruit juice within 24-48 hours?
"For 43 of the 85 drugs now on the list, consumption with grapefruit can be life-threatening, Dr. Bailey said. Grapefruit juice has been found to significantly increase the oral bioavailability of several drugs metabolized by cytochrome P450 enzyme."
This "grapefruit juice effect" may last for 24 to 48 hours after a single 8-oz glass. Therefore, taking medications at a different time as drinking the grapefruit juice will not necessarily avoid the interaction.
The science: http://jpet.aspetjournals.org/content/313/1/154.full.pdf
Basically, these drugs must be detoxified by this enzyme which is normally inhibited by some foods. But, the drugs have toxicity effects when consumed with these foods. Additionally, a large portion of the population has an impairment of this detoxification enzyme which causes drugs to become toxic, regardless of avoiding these foods.
Additionally, many drug-drug combinations cause this same toxicity to develop by inhibiting the CY P450 enzyme.
A list of drugs whose effects are decreased by grapefruit can be found here.
Do you have an impaired CY P450 enzyme gene? Do you have "chemical sensitivity" to pharmaceuticals?
NOTE: Reporting of adverse events and medication errors by healthcare professionals and consumers is voluntary in the United States.
"Health care providers have misconceptions about reporting ADRs.1–3 These misconceptions include the ideas that: 1) All serious ADRs are documented by the time a drug is marketed; 2) It is hard to determine if a drug is responsible for the ADR; 3) ADRs should only be reported if absolute certainty exists that the ADR is related to a particular drug; and, finally, 4) One case reported by an individual physician does not contribute to medical knowledge. Let’s look at each one of these points.
1) As we have seen, rare ADRs are usually NOT documented by the time a drug is marketed.
2) It can be hard to determine if an individual drug caused a reaction in a complicated patient receiving multiple medications. However, the temporal relationship of a reaction with regard to the administration of a new medication can be helpful. Also, biological plausibility (asking if the drug’s mechanism of action makes this possible or likely) can also be helpful. The bottom line is, even when in doubt about whether a drug caused the reaction, report it.
3) A suspicion of an adverse drug reaction should be reported. A health care provider does not have to be absolutely certain that a drug caused a reaction. All reports contribute to the heightening of the awareness of FDA safety scientists as they monitor all of the evidence to evaluate the potential for drug-related toxicity.
4) One individual report CAN make a difference. Many drug withdrawals began with one clinical report that initiated further investigation. In the example case in this module, a single report ultimately led to the removal of terfenadine from the market. This report potentially saved many lives and led to a better understanding of the mechanism involved in causing torsades de pointes. Almost all drugs are now evaluated prior to being released on the market for their potential to induce cardiac arrhythmias, also as a result of this single case report."
Pat Robinson, Wellness Educator
Holistic Researcher & Advocate