MTHFR (C677T) (folate)

[Shannon]

MTHFR activates folate.

With two copies of C677T or one of C677T and one of A1298C, the activation process is slowed down, so you need twice as much.

Interventions include supplemental folate (start with 5-MTHF form, then look further if that doesn't work) and avoiding folic acid. There are also workarounds - betaine and other methyl donors can serve the same purpose.

Naturally occurring food folate is pre-activated. Cool, huh?

Symptoms to look for here are those involved in high homocysteine:
midline defects and neural tube defects
vascular plaques
abnormal clotting
cardiovascular disease
neurologic disease

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[gilamama]

so shannon, what test would i need to do to establish if i have this issue. how would i explain to a dr why i need it? (just on the off chance that they wont have a clue what i am talking about.)

[Shannon]

I asked my regular doctor, and we did a blood test to look for mutations in the MTHFR gene, and it was covered by insurance. We called it prenatal screening. If your kids have midline defects, that would be good motivation to ask for it, as would any family history of stroke/blood clots/cardiovascular problems. Those are all symptoms of high homocysteine, so testing your homocysteine in addition can tell you a lot there, too.

[gilamama]

if homocysteine was high that would mean that prolactin was low? i might be remembering this wrong, i'll have to check later but, i have alot of milk so... (if i remembered what you wrote this wouldn't be an issue) btw you and your dd are super-cute in the movies and thank you soo soo soo much for putting them together and puttign them up. very thoughtful. :)

[Shannon]

Prolactin is inhibited by dopamine. So lots of milk would point towards low dopamine. Which is related to homocysteine, but the line definitely isn't straight.